Article
Nucleotide mutations associated with hepatitis B e antigen negativity.
Journal of medical virology - 1 Jun 2005
Sun XiaoHong, Rokuhara Akinori, Tanaka Eiji, Gad Amal, Mutou Hidetomo, Matsumoto Akihiro, Yoshizawa Kaname, Kiyosawa Kendo
Abstract excerpt
One hundred and forty four patients with chronic hepatitis B were tested to identify new mutations associated with hepatitis B e antigen (HBeAg) negativity, using a full genome sequence analysis. All the patients were Chinese and had hepatitis B virus infection of genotype C. Patients with none of the pre-core or core promoter mutations were significantly (P < 0.001) less common in the group with anti-HBe (13%)...
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