An interleukin-2 receptor gamma chain mutation with normal thymus morphology.

doi:10.1172/JCI119858

Back to search

Article

An interleukin-2 receptor gamma chain mutation with normal thymus morphology.

The Journal of clinical investigation - 15 Dec 1997

Sharfe N, Shahar M, Roifman C M

Abstract excerpt

One of the most common human immunodeficiencies is an X-linked condition arising from mutations of the gamma subunit of the interleukin-2 receptor (IL-2Rgamma). The IL-2Rgamma protein is one chain of the heterotrimeric (alpha, beta, gamma) IL-2 receptor, but also participates in the formation of...

Topics

Animals
COS Cells
Humans
Infant
Janus Kinase 3
Ligands
Male
Mutation
Protein-Tyrosine Kinases
Receptors, Interleukin-2
Severe Combined Immunodeficiency
Thymus Gland

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.