Article
Comparison of five retrovirus vectors containing the human IL-2 receptor gamma chain gene for their ability to restore T and B lymphocytes in the X-linked severe combined immunodeficiency mouse model.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2001
Avilés Mendoza G J, Seidel N E, Otsu M, Anderson S M, Simon-Stoos K, Herrera A, Hoogstraten-Miller S, Malech H L, Candotti F, Puck J M, Bodine D M
Abstract excerpt
X-linked severe combined immunodeficiency (XSCID) is caused by mutations in the IL-2 receptor gamma chain (IL2RG) gene, resulting in absent T lymphocytes and nonfunctional B lymphocytes. Recently T lymphocyte production and B lymphocyte function were restored in XSCID patients infused with autologous stem cells transduced with a retrovirus containing the human IL2RG cDNA. To optimize the expression of human IL2RG...
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