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Article

Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome.

Frontiers in immunology - 1 Jan 2021

Belaid Brahim, Lamara Mahammed Lydia, Mohand Oussaid Aida, Migaud Melanie, Khadri Yasmine, Casanova Jean Laurent, Puel Anne, Ben Halla Nafissa, Djidjik Reda

Abstract excerpt

X-linked severe combined immunodeficiency (X-SCID) is caused by mutations of IL2RG, the gene encoding the interleukin common gamma chain (IL-2Rγ or γc) of cytokine receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Hypomorphic mutations of IL2RG may cause combined immunodeficiencies with atypical clinical and immunological presentations. Here, we report a clinical, immunological, and functional...

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Identifiers

PMID: 34248995
DOI: 10.3389/fimmu.2021.696350
PMCID: PMC8264782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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