Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.

Article

Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.

Oncogene - 1 Oct 1993

Kovar H, Auinger A, Jug G, Aryee D, Zoubek A, Salzer-Kuntschik M, Gadner H

Abstract excerpt

The p53 and MDM2 genes are part of a physiological pathway frequently impaired in human cancer. With the exception of tumours occasionally associated with hereditary predisposition, childhood malignancies have not been studied in detail yet. This is the first report on the analysis of p53 and MDM...

Topics

Base Sequence
Codon
Exons
Genes, p53
Humans
Molecular Sequence Data
Mutation
Oncogenes
Sarcoma, Ewing
Tumor Cells, Cultured

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