Overexpression of MDM2 in acute childhood lymphoblastic leukemia.

doi:10.3109/08880019809018313

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Article

Overexpression of MDM2 in acute childhood lymphoblastic leukemia.

Pediatric hematology and oncology - 1 Jan 2000

Gustafsson B, Stål O, Gustafsson B

Abstract excerpt

Mutation of the TP53 gene is one of the most common molecular alterations in a variety of tumors, but it occurs infrequently in childhood and adult hematological malignancies. Protein accumulation often results from mutations that lead to inactivation of the p53 protein. Other causes of functiona...

Topics

Adolescent
Adult
Biomarkers, Tumor
Child
Child, Preschool
Gene Expression Regulation, Neoplastic
Humans
Infant
Mutation
Neoplasm Proteins
Nuclear Proteins
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2
Recurrence
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9842645
DOI: 10.3109/08880019809018313

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9842645-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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