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Article

Overexpression of MDM2 in acute childhood lymphoblastic leukemia.

Pediatric hematology and oncology - 1 Jan 2000

Gustafsson B, Stål O, Gustafsson B

Abstract excerpt

Mutation of the TP53 gene is one of the most common molecular alterations in a variety of tumors, but it occurs infrequently in childhood and adult hematological malignancies. Protein accumulation often results from mutations that lead to inactivation of the p53 protein. Other causes of functional inactivation of the p53 protein include stabilization of p53 via proteins such as MDM2, an oncoprotein capable of...

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Identifiers

PMID: 9842645
DOI: 10.3109/08880019809018313

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Overexpression of MDM2 in acute childhood lymphoblastic leukemia.PMID 9842645Read ↗

Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.Semantic proximity Read ↗

The human MDM-2 oncogene is overexpressed in leukemiasSemantic proximity Read ↗

The human MDM-2 oncogene is overexpressed in leukemiasSemantic proximity Read ↗

Overexpression of the<i>MDM2</i>Oncogene in Leukemia and LymphomaSemantic proximity Read ↗

Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosisSemantic proximity Read ↗

Over‐expression of the MDM<sub>2</sub> gene is found in some cases of haematological malignanciesSemantic proximity Read ↗

MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemiaSemantic proximity Read ↗

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The MDM2 gene amplification databaseSemantic proximity Read ↗

Stabilization of the MDM2 oncoprotein by mutant p53.Semantic proximity Read ↗

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