Article
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood - 15 Mar 1995
Zhou M, Yeager A M, Smith S D, Findley H W
Abstract excerpt
The wild-type (wt) p53 tumor suppressor gene is commonly inactivated in human malignancies, either by mutations or by loss of expression. An additional proposed mechanism for inactivation of wt-p53 is amplification of the murine double minute 2 (MDM2) gene and overexpression of the MDM2 protein, which binds to p53 and eliminates its tumor suppressor function. To investigate a potential role for MDM2 in the...
Topics
- Blotting, Southern
- Child
- Gene Expression Regulation, Leukemic
- Genes, p53
- Humans
- Mutation
- Nuclear Proteins
- Polymorphism, Single-Stranded Conformational
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Proto-Oncogene Proteins