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Article

<i>MDM2</i> and <i>CDK4</i> gene amplification in Ewing's sarcoma

1 Feb 1995

Abstract excerpt

Abstract Amplification of the MDM2 gene, which maps to chromosome band 12q13 and encodes a p53‐binding protein, may result in functional inactivation of p53 and has been observed in various bone and soft tissue sarcomas. Published studies have included few cases of Ewing's sarcoma (ES) or peripheral neuroectodermal tumour (PNET), a tumour group in which alterations of the p53 pathway have so far not been...

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PMID: 7738717
DOI: 10.1002/path.1711750209

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