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Article

In situ quantification of aberrant p53 in colorectal neoplasia.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Jan 2000

Smith Steven Jay, Neugut Alfred, Heitjan Daniel, Forde Kenneth, Holt Peter, Santella Regina M, Jiin-Chyuan Luo, Carney Walter, Ward Llewelyn, Brandt-Rauf Paul W

Abstract excerpt

Aberrant p53 protein accumulation was measured immunohistologically in 342 colorectal paraffin-embedded tissue sections from 115 patients (24 with adenocarcinoma, 59 with adenoma and 32 'hospital controls'). Subjective scoring was compared with quantitative cell imaging, including dichotomous (p53+/p53-) status, ng p53mut mg(-1) enterocyte protein, and tumour burden and patient body 'burden' of aberrant p53. A...

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Identifiers

PMID: 12944180
DOI: 10.1080/1354750031000138676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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