Article
Serum anti-p53 in relation to mutations across the entire translated p53 gene in colorectal carcinomas.
International journal of oncology - 1 Sept 2001
Forslund A, Kressner U, Lindmark G, Inganäs M, Lundholm K
Abstract excerpt
Previous reports have claimed that antibodies to mutated p53 protein indicate poor outcome in malignant disease. The mechanism behind this highly specific process is unclear, although it has been claimed that certain DNA alterations are prone to induction of immune response, since wild-type p53 is almost never immunogenic. The aim of the present analysis was to evaluate whether the presence of anti-p53 was...
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