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Article

Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment.

1 Oct 1993

Abstract excerpt

The anti-idiotypic (anti-Id) antibody (Ab) 9G4 binds a cross-reactive idiotope (CRI) present in a select group of human autoantibodies. This Id has been localized to the portion of immunoglobulin (Ig) heavy (H) chains encoded by the VH4-21 gene segment, a member of the human VH4 family. This gene segment is utilized by essentially all cold agglutinin (CA) Abs with I/i specificity isolated from patients with CA...

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Identifiers

PMID: 8376944
DOI: 10.1084/jem.178.4.1419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment.PMID 8376944Read ↗

Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype.Semantic proximity Read ↗

The I binding specificity of human VH 4-34 (VH 4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3.Semantic proximity Read ↗

VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificitiesSemantic proximity Read ↗

Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments.Semantic proximity Read ↗

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Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigensSemantic proximity Read ↗

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