VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities

Abstract excerpt

We previously reported that human autoantibodies with cold agglutinin activity contained a single human VH gene segment (VH4-21) which was also responsible for the cross-idiotypic specificity characteristic of the cold agglutinin response. To confirm and extend this observation we have analyzed at the nucleotide level the H and L chains of six new cold agglutinin molecules derived from different patients. We...

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