Article
Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1991
Pascual V, Victor K, Lelsz D, Spellerberg M B, Hamblin T J, Thompson K M, Randen I, Natvig J, Capra J D, Stevenson F K
Abstract excerpt
Cold agglutinins are human autoantibodies, usually of the IgM class, which agglutinate RBC at low temperature. The major subset recognizes the I/i carbohydrate Ag, and many of these antibodies bear cross-reacting idiotypic determinants. An anti-idiotypic mAb that is specific for one of the idiotopes largely confined to cold agglutinins has been used to identify and monitor tumor cells that secrete these molecules...
Topics
- Aged
- Agglutinins
- Amino Acid Sequence
- Autoantibodies
- Base Sequence
- Cell Line
- Cold Temperature
- Cross Reactions
- Cryoglobulins
- Epitopes