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Article

Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments.

Blood - 15 May 1994

Riboldi P, Gaidano G, Schettino E W, Steger T G, Knowles D M, Dalla-Favera R, Casali P

Abstract excerpt

We analyzed the reactivity and the structure of the VH and VL segments of two IgM monoclonal antibodies (MoAbs) produced by spontaneously in vitro outgrowing cell lines, HBL-2 and HBL-3, established from two acquired immunodeficiency syndrome (AIDS) patients with Epstein-Barr virus (EBV)-negative Burkitt's lymphoma (BL). These B-cell clones were representative of the respective neoplastic parental clones, as...

Topics

Agglutinins
Amino Acid Sequence
Antibodies, Monoclonal
Base Sequence
Burkitt Lymphoma
Cryoglobulins
Genes, Immunoglobulin
Humans
I Blood-Group System
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin M

Immunoglobulin Variable Region

Lymphoma, AIDS-Related

Molecular Sequence Data

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 8180391
PMCID: PMC4667548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8180391-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments.PMID 8180391Read ↗

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