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Article

Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens

1 Nov 1991

Abstract excerpt

To investigate the molecular basis of the autoimmune response to the related i and I carbohydrate antigens, we studied cold agglutinins (CA) from B-cell clones and from the peripheral circulation of patients with lymphoproliferative syndromes. Sequence analyses of expressed variable region genes indicate that both anti-i and anti-I specificities from B-cell clones from two patients are encoded by the VH4.21 or a...

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Identifiers

PMID: 1657249
DOI: 10.1182/blood.v78.9.2372.2372

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Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigensPMID 1657249Read ↗

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