Article
The fission yeast RPA51 is a functional homolog of the budding yeast A49 subunit of RNA polymerase I and required for maximizing transcription of ribosomal DNA.
Genes & genetic systems - 1 Jun 2003
Nakagawa Kaori, Hisatake Koji, Imazawa Yukiko, Ishiguro Akira, Matsumoto Masahito, Pape Louise, Ishihama Akira, Nogi Yasuhisa
Abstract excerpt
Saccharomyces cerevisiae A49 and mouse PAF53 are subunits specific to RNA polymerase I (Pol I) in eukaryotes. It has been known that Pol I without A49 or PAF53 maintains non-specific transcription activities but a molecular role(s) of A49 (and PAF53) remains totally unknown. We studied the fission yeast gene encoding a protein of 415 amino acids exhibiting 30% and 19% identities to A49 and PAF53, respectively. We...
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