Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair.

doi:10.1038/365274a0

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Article

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair.

Nature - 16 Sept 1993

Strand M, Prolla T A, Liskay R M, Petes T D

Abstract excerpt

The genomes of all eukaryotes contain tracts of DNA in which a single base or a small number of bases is repeated. Expansions of such tracts have been associated with several human disorders including the fragile X syndrome. In addition, simple repeats are unstable in certain forms of colorectal...

Topics

DNA Repair
DNA Replication
DNA, Fungal
DNA-Directed DNA Polymerase
Genes, Fungal
Mutation
Nucleic Acid Heteroduplexes
Plasmids
Polydeoxyribonucleotides
Recombination, Genetic
Repetitive Sequences, Nucleic Acid

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