Article
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair.
Nature - 16 Sept 1993
Strand M, Prolla T A, Liskay R M, Petes T D
Abstract excerpt
The genomes of all eukaryotes contain tracts of DNA in which a single base or a small number of bases is repeated. Expansions of such tracts have been associated with several human disorders including the fragile X syndrome. In addition, simple repeats are unstable in certain forms of colorectal cancer, suggesting a defect in DNA replication or repair. We show here that mutations in any three yeast genes involved...
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