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Article

Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.

Molecular and cellular biology - 1 Dec 2001

Sia E A, Dominska M, Stefanovic L, Petes T D

Abstract excerpt

The stability of simple repetitive DNA sequences (microsatellites) is a sensitive indicator of the ability of a cell to repair DNA mismatches. In a genetic screen for yeast mutants with elevated microsatellite instability, we identified strains containing point mutations in the yeast mismatch repair genes, MSH2, MSH3, MLH1, and PMS1. Some of these mutations conferred phenotypes significantly different from those...

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Source

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Identifiers

PMID: 11689704
DOI: 10.1128/MCB.21.23.8157-8167.2001
PMCID: PMC99980

Genes

MSH2
MLH1
MSH3
PMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.PMID 11689704Read ↗

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Microsatellite Instability in Yeast: Dependence on Repeat Unit Size and DNA Mismatch Repair GenesSemantic proximity Read ↗

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Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.Semantic proximity Read ↗

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair.Semantic proximity Read ↗

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Mutator phenotype due to loss of heterozygosity in diploid yeast strains with mutations in MSH2 and MLH1.Semantic proximity Read ↗

Microsatellite Instability in Yeast: Dependence on the Length of the MicrosatelliteSemantic proximity Read ↗

The rate of spontaneous mutations in yeast deficient for MutSβ function.Semantic proximity Read ↗

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