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Article

Length and sequence heterozygosity differentially affect HRAS1 minisatellite stability during meiosis in yeast.

Genetics - 1 Jun 2005

Jauert Peter A, Kirkpatrick David T

Abstract excerpt

Minisatellites, one of the major classes of repetitive DNA sequences in eukaryotic genomes, are stable in somatic cells but destabilize during meiosis. We previously established a yeast model system by inserting the human Ha-ras/HRAS1 minisatellite into the HIS4 promoter and demonstrated that our system recapitulates all of the phenotypes associated with the human minisatellite. Here we demonstrate that meiotic...

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Identifiers

PMID: 15834153
DOI: 10.1534/genetics.104.026278
PMCID: PMC1450406

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