Article
Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.
Science (New York, N.Y.) - 14 Jul 1995
Johnson R E, Kovvali G K, Prakash L, Prakash S
Abstract excerpt
Simple repetitive DNA sequences are unstable in human colorectal cancers and a variety of other cancers. Mutations in the DNA mismatch repair genes MSH2, MLH1, and PMS1 result in elevated rates of spontaneous mutation and cause a marked increase in the instability of simple repeats. Compared with the wild type, a null mutation in the yeast RTH1 gene, which encodes a 5' to 3' exonuclease, was shown to increase the...
Topics
- Adaptor Proteins, Signal Transducing
- Carrier Proteins
- DNA Repair
- DNA, Fungal
- DNA-Binding Proteins
- Exodeoxyribonuclease V
- Exodeoxyribonucleases
- Fungal Proteins
- Genes, Fungal
- MutL Protein Homolog 1
- MutL Proteins