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Article

Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 1995

Strand M, Earley M C, Crouse G F, Petes T D

Abstract excerpt

Eukaryotic genomes contain tracts of DNA in which a single base or a small number of bases are repeated (microsatellites). Mutations in the yeast DNA mismatch repair genes MSH2, PMS1, and MLH1 increase the frequency of mutations for normal DNA sequences and destabilize microsatellites. Mutations of human homologs of MSH2, PMS1, and MLH1 also cause microsatellite instability and result in certain types of cancer....

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Source

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Identifiers

PMID: 7479796
DOI: 10.1073/pnas.92.22.10418
PMCID: PMC40808

Genes

MSH3
MLH1
MSH2
PMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.PMID 7479796Read ↗

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The yeast gene MSH3 defines a new class of eukaryotic MutS homologues.Semantic proximity Read ↗

Microsatellite Instability in Yeast: Dependence on Repeat Unit Size and DNA Mismatch Repair GenesSemantic proximity Read ↗

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MSH3 deficiency is not sufficient for a mutator phenotype in Chinese hamster ovary cells.Semantic proximity Read ↗

Requirement of the yeast RTH1 5' to 3' exonuclease for the stability of simple repetitive DNA.Semantic proximity Read ↗

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