Article
Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 1995
Strand M, Earley M C, Crouse G F, Petes T D
Abstract excerpt
Eukaryotic genomes contain tracts of DNA in which a single base or a small number of bases are repeated (microsatellites). Mutations in the yeast DNA mismatch repair genes MSH2, PMS1, and MLH1 increase the frequency of mutations for normal DNA sequences and destabilize microsatellites. Mutations...
Topics
- Base Sequence
- DNA Primers
- DNA, Satellite
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Fungal
- Humans
- Molecular Sequence Data
- Multidrug Resistance-Associated Proteins
- MutS Homolog 3 Protein
- Mutagenesis
- Mutation
- Neoplasms
- Polymerase Chain Reaction
- Proteins