Article
Yeast phenotype classifies mammalian protein kinase C cDNA mutants.
Molecular and cellular biology - 1 Aug 1993
Riedel H, Su L, Hansen H
Abstract excerpt
The phorbol ester receptor protein kinase C (PKC) gene family encodes essential mediators of eukaryotic cellular signals. Molecular dissection of their mechanisms of action has been limited in part by the lack of random mutagenesis approaches and by the complexity of signaling pathways in mammalian cells which involve multiple PKC isoforms. Here we present a rapid screen which permits the quantification of...
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