Article
The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.
Genes & development - 1 Jul 1995
Kamada Y, Jung U S, Piotrowski J, Levin D E
Abstract excerpt
The PKC1 gene of budding yeast encodes a homolog of the alpha, beta, and gamma isoforms of mammalian PKC that is proposed to regulate a MAPK-activation pathway. Mutants in this pathway undergo cell lysis resulting from a deficiency in cell wall construction when they attempt to grow at elevated temperatures. We show that the PKC1-regulated pathway is important for induced thermotolerance and that the MPK1 protein...
Topics
- Base Sequence
- Calcium-Calmodulin-Dependent Protein Kinases
- Catalase
- Cell Membrane
- DNA Primers
- Enzyme Activation
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genotype