Article
The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.
Genes & development - 1 Jul 1995
Kamada Y, Jung U S, Piotrowski J, Levin D E
Abstract excerpt
The PKC1 gene of budding yeast encodes a homolog of the alpha, beta, and gamma isoforms of mammalian PKC that is proposed to regulate a MAPK-activation pathway. Mutants in this pathway undergo cell lysis resulting from a deficiency in cell wall construction when they attempt to grow at elevated temperatures. We show that the PKC1-regulated pathway is important for induced thermotolerance and that the MPK1 protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.