Article
A codon 248 p53 mutation retains tumor suppressor function as shown by enhancement of tumor growth by antisense p53.
Cancer research - 15 Sept 1993
Mukhopadhyay T, Roth J A
Abstract excerpt
Codon 248 in domain iv of the highly conserved region of the p53 gene is a frequent site of mutations associated with sporadic cancers and the familial cancer syndrome (Li-Fraumeni syndrome). Therefore, a characterization of the functional significance of a codon 248 mutation is of interest. We used antisense RNA methodology to study the role of the wild-type and mutated p53 gene in cell growth and tumorigenesis....
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