A codon 248 p53 mutation retains tumor suppressor function as shown by enhancement of tumor growth by antisense p53.

Article

A codon 248 p53 mutation retains tumor suppressor function as shown by enhancement of tumor growth by antisense p53.

Cancer research - 15 Sept 1993

Mukhopadhyay T, Roth J A

Abstract excerpt

Codon 248 in domain iv of the highly conserved region of the p53 gene is a frequent site of mutations associated with sporadic cancers and the familial cancer syndrome (Li-Fraumeni syndrome). Therefore, a characterization of the functional significance of a codon 248 mutation is of interest. We u...

Topics

Animals
Base Sequence
Cell Division
Codon
Genes, p53
Humans
Mice
Molecular Sequence Data
Mutation
Neoplasms, Experimental
RNA, Antisense
Tumor Cells, Cultured

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