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Article

p53 directs conformational change and translation initiation blockade of human fibroblast growth factor 2 mRNA.

Oncogene - 2 Aug 2001

Galy B, Créancier L, Prado-Lourenço L, Prats A C, Prats H

Abstract excerpt

Tumour suppressor p53 has been shown to inhibit fibroblast growth factor 2 expression post-transcriptionally in cultured cells. Here we have investigated the mechanism responsible for this post-transcriptional blockade. Deletion mutagenesis of the FGF-2 mRNA leader revealed the requirement of at least four RNA cis-acting elements to mediate the inhibitory effect of p53 in SK-Hep-1 transfected cells, suggesting...

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Source

Identifiers

PMID: 11498784
DOI: 10.1038/sj.onc.1204630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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