Article
A molecular approach to estimating the human deleterious mutation rate.
Human mutation - 1 Jan 1993
Kondrashov A S, Crow J F
Abstract excerpt
We propose a method of measuring the human genomic deleterious mutation rate based on comparison of the rate of evolution per nucleotide per generation of neutral sequences, microN, with the overall rate of evolution of unique sequence DNA, microO. Data on microN, which are based on pseudogenes, permit an estimate of the total zygotic (twice the genomic) mutation rate, UT = 2 microNn = 2(2 x 10(-8)(3 x 10(9))...
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