Article
Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.
PLoS genetics - 1 Jan 2013
Kiezun Adam, Pulit Sara L, Francioli Laurent C, van Dijk Freerk, Swertz Morris, Boomsma Dorret I, van Duijn Cornelia M, Slagboom P Eline, van Ommen G J B, Wijmenga Cisca, de Bakker Paul I W, Sunyaev Shamil R
Abstract excerpt
Large-scale population sequencing studies provide a complete picture of human genetic variation within the studied populations. A key challenge is to identify, among the myriad alleles, those variants that have an effect on molecular function, phenotypes, and reproductive fitness. Most non-neutral variation consists of deleterious alleles segregating at low population frequency due to incessant mutation. To date,...
Topics
- Alleles
- Evolution, Molecular
- Gene Frequency
- Genetic Drift
- Genetic Variation
- Genetics, Population
- Genome, Human
- Humans
- Models, Theoretical
- Selection, Genetic