Article
How many deleterious mutations are there in the human genome?
Medical hypotheses - 1 May 2001
Morris J A
Abstract excerpt
An estimate of the number of deleterious mutations in the human genome is made using data on the frequency of rare recessive disease in cousin marriages and in the general population. Sexual reproduction ensures that deleterious mutations are distributed at random in zygotes with an approximate Poisson distribution. The mean of this distribution is the sum of the mean number of deleterious mutations in zygotes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.