Article
Yeast bZip proteins mediate pleiotropic drug and metal resistance.
The Journal of biological chemistry - 5 Sept 1993
Wu A, Wemmie J A, Edgington N P, Goebl M, Guevara J L, Moye-Rowley W S
Abstract excerpt
Saccharomyces cerevisiae contains a group of transcription factors related to mammalian c-Jun. This yeast Jun-family of proteins consists of GCN4, a regulator of genes involved in amino acid biosynthesis, and yAP-1, a factor conferring pleiotropic drug resistance when overexpressed. In the work described here, we show that a third member of the yeast Jun-family exists. This protein has been designated CAD1 and...
Topics
- Amino Acid Sequence
- Base Sequence
- Basic-Leucine Zipper Transcription Factors
- Binding Sites
- Cadmium
- Cycloheximide
- DNA, Fungal
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Fungal Proteins
- G-Box Binding Factors
- Gene Expression
- Genes, Fungal
- Molecular Sequence Data