Article
Transcriptional activation mediated by the yeast AP-1 protein is required for normal cadmium tolerance.
The Journal of biological chemistry - 20 May 1994
Wemmie J A, Wu A L, Harshman K D, Parker C S, Moye-Rowley W S
Abstract excerpt
The yeast YAP1 gene encodes a transcriptional regulatory protein that utilizes a basic region-leucine zipper (bZip) DNA-binding domain to recognize its cognate DNA element. A synthetic reporter gene containing a SV40 AP-1 response element (ARE) cloned upstream of a TRP5 promoter-lacZ gene fusion shows yAP-1-dependent transactivation in vivo. Recent work has shown that changes in the gene dosage of this factor can...
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