Article
The bromodomain-containing protein Bdf1p acts as a phenotypic and transcriptional multicopy suppressor of YAF9 deletion in yeast.
Molecular microbiology - 1 Aug 2004
Bianchi Michele M, Costanzo Giovanna, Chelstowska Anna, Grabowska Dorota, Mazzoni Cristina, Piccinni Eugenia, Cavalli Antonella, Ciceroni Francesca, Rytka Joanna, Slonimski Piotr P, Frontali Laura, Negri Rodolfo
Abstract excerpt
It was observed previously that the deletion of the open reading frame YNL107w (YAF9) was highly pleiotropic in yeast and caused defective growth phenotypes in the presence of several unrelated inhibitors, including caesium chloride. We have selected multicopy extragenic suppressor genes, revealing that this phenotype can be suppressed by overdosing the transcription factors BDF1 and GAT1 in the yaf9Delta strain....
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