Weak organic acids trigger conformational changes of the yeast transcription factor War1 in vivo to elicit stress adaptation.

doi:10.1074/jbc.M803095200

Article

Weak organic acids trigger conformational changes of the yeast transcription factor War1 in vivo to elicit stress adaptation.

The Journal of biological chemistry - 12 Sept 2008

Gregori Christa, Schüller Christoph, Frohner Ingrid E, Ammerer Gustav, Kuchler Karl

Abstract excerpt

The Saccharomyces cerevisiae zinc cluster regulator War1 mediates an essential transcriptional and adaptive response to weak organic acid stress. Here we investigate the mechanism of War1 activation upon weak acid stress. We identified several gain-of-function WAR1 alleles mapping to the central War1 region. These mutations constitutively increase levels of the plasma membrane ABC transporter Pdr12, the main War1...

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Weak organic acids trigger conformational changes of the yeast transcription factor War1 in vivo to elicit stress adaptation.

Abstract excerpt

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Weak organic acids trigger conformational changes of the yeast transcription factor War1 in vivo to elicit stress adaptation.

Abstract excerpt

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