Article
Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a new central regulatory domain.
Molecular & general genetics : MGG - 1 Oct 1997
Nourani A, Papajova D, Delahodde A, Jacq C, Subik J
Abstract excerpt
In the yeast Saccharomyces cerevisiae mutations in the genes encoding the transcription factors Pdr1p and Pdr3p are known to be associated with pleiotropic drug resistance mediated by the overexpression of the efflux pumps Pdr5p, Snq2p, and Yor1p. Mutagenesis of PDR3 was used to induce multidrug...
Topics
- ATP-Binding Cassette Transporters
- Alleles
- Amino Acid Sequence
- Antifungal Agents
- Binding Sites
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Fungal Proteins
- Genes, Dominant
- Genes, Fungal
- Genes, Regulator
- Membrane Proteins
- Molecular Sequence Data
- Mutagenesis
- Phenotype
- Promoter Regions, Genetic
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins