Article
Positive association in the absence of linkage suggests a minor role for the glucokinase gene in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus amongst south Indians.
Diabetologia - 1 Jul 1993
McCarthy M I, Hitchins M, Hitman G A, Cassell P, Hawrami K, Morton N, Mohan V, Ramachandran A, Snehalatha C, Viswanathan M
Abstract excerpt
Mutations of the glucokinase gene have been implicated in the development of glucose intolerance in pedigrees with maturity-onset diabetes of the young. However, the contribution of the glucokinase gene to the aetiology of common Type 2 (non-insulin-dependent) diabetes mellitus is uncertain. We have studied the role of the glucokinase gene in the pathogenesis of Type 2 diabetes in South Indians, using both...
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