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Article

Glucokinase gene is genetic marker for NIDDM in American blacks.

Diabetes - 1 Jul 1992

Chiu K C, Province M A, Permutt M A

Abstract excerpt

Glucokinase (ATP:D-glucose-6-phosphotransferase), expressed exclusively in liver and pancreatic islet beta-cells, catalyzes the first step of glycolysis and acts as glucose sensor and metabolic signal generator in these tissues. The enzyme plays a key role in glucose homeostasis and as such is an excellent candidate for inherited defects predisposing to non-insulin-dependent diabetes mellitus (NIDDM). A...

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Identifiers

PMID: 1612198
DOI: 10.2337/diab.41.7.843

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