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Article

Glucokinase gene polymorphisms: a genetic marker for glucose intolerance in a cohort of elderly Finnish men.

Diabetic medicine : a journal of the British Diabetic Association - 1 Mar 1994

McCarthy M I, Hitman G A, Hitchins M, Riikonen A, Stengård J, Nissinen A, Tuomilehto-Wolf E, Tuomilehto J

Abstract excerpt

Although mutations in the glucokinase gene are implicated in the pathogenesis of glucose intolerance in pedigrees with maturity-onset diabetes of the young, the role of such mutations in typical Type 2 diabetes is poorly characterized. We studied a cohort of elderly men born (between 1900 and 1919) in two Finnish communities and exhibiting a continuous spectrum of glucose tolerance at assessments made in 1984 and...

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Identifiers

PMID: 8200207
DOI: 10.1111/j.1464-5491.1994.tb02020.x

Genes

GCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Glucokinase gene polymorphisms: a genetic marker for glucose intolerance in a cohort of elderly Finnish men.PMID 8200207Read ↗

Screening of mutations and polymorphisms in the glucokinase gene in Czech diabetic and healthy control populations.Semantic proximity Read ↗

A novel heterozygous mutation in the glucokinase gene is responsible for an early-onset mild form of maturity-onset diabetes of the young, type 2.Semantic proximity Read ↗

Microsatellite polymorphisms at the glucokinase locus: a population association study in Caucasian type 2 diabetic subjects.Semantic proximity Read ↗

Positive association in the absence of linkage suggests a minor role for the glucokinase gene in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus amongst south Indians.Semantic proximity Read ↗

Polymorphic microsatellite repeat markers at the glucokinase gene locus are positively associated with NIDDM in Japanese.Semantic proximity Read ↗

[Fasting hyperglycaemia and polymorphism in glucokinase promoter (rs1799884)].Semantic proximity Read ↗

Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies.Semantic proximity Read ↗

Linkage of type 2 diabetes to the glucokinase gene.Semantic proximity Read ↗

CA-repeated microsatellite polymorphism of the glucokinase gene and its association with non-insulin-dependent diabetes mellitus in Taiwanese.Semantic proximity Read ↗

A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.Semantic proximity Read ↗

Two microsatellite repeat polymorphisms flanking opposite ends of the human glucokinase gene: use in haplotype analysis of Welsh Caucasians with type 2 (non-insulin-dependent) diabetes mellitus.Semantic proximity Read ↗

Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.Semantic proximity Read ↗

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