Article
A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.
The Journal of clinical investigation - 1 Aug 1993
Samani N J, Lodwick D, Vincent M, Dubay C, Kaiser M A, Kelly M P, Lo M, Harris J, Sassard J, Lathrop M
Abstract excerpt
The role of the kidney in initiating hypertension has been much debated. Here we demonstrate that a recently identified gene of yet unknown function, termed SA, which is differentially expressed in the kidney of the spontaneously hypertensive rat, cosegregates with an increase in blood pressure in F2 rats derived from a cross of the spontaneously hypertensive rat with normotensive Wistar-Kyoto rats, accounting...
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