Article
A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.
The Journal of clinical investigation - 1 Aug 1993
Samani N J, Lodwick D, Vincent M, Dubay C, Kaiser M A, Kelly M P, Lo M, Harris J, Sassard J, Lathrop M
Abstract excerpt
The role of the kidney in initiating hypertension has been much debated. Here we demonstrate that a recently identified gene of yet unknown function, termed SA, which is differentially expressed in the kidney of the spontaneously hypertensive rat, cosegregates with an increase in blood pressure i...
Topics
- Aging
- Analysis of Variance
- Animals
- Base Sequence
- Blood Pressure
- Blotting, Southern
- Chromosome Mapping
- Crosses, Genetic
- DNA
- Diastole
- Female
- Gene Expression
- Genetic Linkage
- Genotype
- Hypertension