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Article

Identification of a candidate gene responsible for the high blood pressure of spontaneously hypertensive rats.

Journal of hypertension - 1 Oct 1992

Iwai N, Inagami T

Abstract excerpt

OBJECTIVE: We have recently isolated a gene, designated as the SA gene, which is more than 10 times more abundantly expressed in the kidneys of spontaneously hypertensive rats (SHR) than in those of Wistar-Kyoto (WKY) rats. To address the issue whether the SA gene is one of the genes responsible for the hypertension of SHR, a genetic cosegregation analysis of the blood pressure values with the genotypes in an F2...

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Source

Identifiers

PMID: 1361506
DOI: 10.1097/00004872-199210000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a candidate gene responsible for the high blood pressure of spontaneously hypertensive rats.PMID 1361506Read ↗

Further evidence of the SA gene as a candidate gene contributing to the hypertension in spontaneously hypertensive rat.Semantic proximity Read ↗

A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.Semantic proximity Read ↗

Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome 1.Semantic proximity Read ↗

The rat SA gene shows genotype-dependent tissue-specific expression.Semantic proximity Read ↗

Role of genetic polymorphism in the SA gene on the blood pressure and prognosis of renal function in patients with immunoglobulin A nephropathy.Semantic proximity Read ↗

Re-evaluation of the SA gene in spontaneously hypertensive and Wistar-Kyoto rats.Semantic proximity Read ↗

[Cosegregation studies in spontaneously hypertensive rats].Semantic proximity Read ↗

Cosegregation of spontaneously hypertensive rat renin gene with elevated blood pressure in an F2 generation.Semantic proximity Read ↗

Genetic analysis of the SA and Na+/K+-ATPase alpha1 genes in the Milan hypertensive rat.Semantic proximity Read ↗

Genetic dissection of region around the Sa gene on rat chromosome 1: evidence for multiple loci affecting blood pressure.Semantic proximity Read ↗

Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains.Semantic proximity Read ↗

Blood pressure cosegregates with a microsatellite of angiotensin I converting enzyme (ACE) in F2 generation from a cross between original normotensive Wistar-Kyoto rat (WKY) and stroke-prone spontaneously hypertensive rat (SHRSP).Semantic proximity Read ↗

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