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Article

Cytochrome P4504A genotype cosegregates with hypertension in Dahl S rats.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 1996

Stec D E, Deng A Y, Rapp J P, Roman R J

Abstract excerpt

Recent studies indicate that the production of 20-HETE by a P4504A2 enzyme in the outer medulla of the kidney is reduced in Dahl salt-sensitive (SS/Jr) rats, but the contribution of this abnormality to the elevation in loop Cl- transport and development of hypertension in this model is unknown. THe present study found that alleles at the locus for the P4504A2 gene cosegregate with blood pressure in an F2...

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Identifiers

PMID: 8613204
DOI: 10.1161/01.hyp.27.3.564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cytochrome P4504A genotype cosegregates with hypertension in Dahl S rats.PMID 8613204Read ↗

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Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channelSemantic proximity Read ↗

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A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure.Semantic proximity Read ↗

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