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Article

Determinants of substrate specificity in omega-aminotransferases.

The Journal of biological chemistry - 28 Oct 2005

Markova Michaela, Peneff Caroline, Hewlins Michael J E, Schirmer Tilman, John Robert A

Abstract excerpt

Ornithine aminotransferase and 4-aminobutyrate aminotransferase are related pyridoxal phosphate-dependent enzymes having different substrate specificities. The atomic structures of these enzymes have shown (i) that active site differences are limited to the steric positions occupied by two tyrosine residues in ornithine aminotransferase and (ii) that, uniquely among related, structurally characterized...

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Identifiers

PMID: 16096275
DOI: 10.1074/jbc.M506977200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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