Article
Transcytosis of the polymeric Ig receptor requires phosphorylation of serine 664 in the absence but not the presence of dimeric IgA.
Cell - 30 Jul 1993
Hirt R P, Hughes G J, Frutiger S, Michetti P, Perregaux C, Poulain-Godefroy O, Jeanguenat N, Neutra M R, Kraehenbuhl J P
Abstract excerpt
MDCK cells expressing the polymeric immunoglobulin (poly-Ig) receptor, cocultured with IgA-producing hybridoma cells, transported dimeric IgA (dIgA) from the basolateral into the lumenal compartment, where it was recovered as secretory component-dIgA complexes. The tail of the receptor was phosph...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Transport
- Cell Polarity
- Cells, Cultured
- Culture Techniques
- Dogs
- Epithelium
- Hybridomas
- Immunoglobulin A
- Kidney