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Article

Structural requirements for the interaction of human IgA with the human polymeric Ig receptor.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2005

Lewis Melanie J, Pleass Richard J, Batten Margaret R, Atkin Julie D, Woof Jenny M

Abstract excerpt

Transport of polymeric IgA onto mucosal surfaces to become secretory IgA is mediated by the polymeric Ig receptor (pIgR). To study the interaction of human dimeric IgA (dIgA) (the predominant form of IgA polymer) with the human pIgR (hpIgR), we generated recombinant wild-type dIgA1 and dIgA2m(1) and various mutant dIgA1 and analyzed their interaction with a recombinant human secretory component and...

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Identifiers

PMID: 16272325
DOI: 10.4049/jimmunol.175.10.6694

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