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Article

Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis.

Science (New York, N.Y.) - 11 May 1990

Casanova J E, Breitfeld P P, Ross S A, Mostov K E

Abstract excerpt

The endosomal compartment of polarized epithelial cells is a major crossroads for membrane traffic. Proteins entering this compartment from the cell surface are sorted for transport to one of several destinations: recycling to the original cell surface, targeting to lysosomes for degradation, or transcytosis to the opposite surface. The polymeric immunoglobulin receptor (pIgR), which is normally transcytosed from...

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Identifiers

PMID: 2110383
DOI: 10.1126/science.2110383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis.PMID 2110383Read ↗

Transcytosis of the polymeric Ig receptor requires phosphorylation of serine 664 in the absence but not the presence of dimeric IgA.Semantic proximity Read ↗

Deletions in the cytoplasmic domain of the polymeric immunoglobulin receptor differentially affect endocytotic rate and postendocytotic traffic.Semantic proximity Read ↗

Identification of a cytoplasmic signal for apical transcytosis.Semantic proximity Read ↗

Polarized traffic towards the cell surface: how to find the routeSemantic proximity Read ↗

Dimerization of the polymeric immunoglobulin receptor controls its transcytotic trafficking.Semantic proximity Read ↗

Transduction of basolateral-to-apical signals across epithelial cells: ligand-stimulated transcytosis of the polymeric immunoglobulin receptor requires two signals.Semantic proximity Read ↗

Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain.Semantic proximity Read ↗

Intracellular routing of wild-type and mutated polymeric immunoglobulin receptor in hippocampal neurons in culture.Semantic proximity Read ↗

Galectin-4-mediated transcytosis of transferrin receptor.Semantic proximity Read ↗

Domain deletions in the human polymeric Ig receptor disclose differences between its dimeric IgA and pentameric IgM interaction.Semantic proximity Read ↗

A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression.Semantic proximity Read ↗

A di-leucine sequence and a cluster of acidic amino acids are required for dynamic retention in the endosomal recycling compartment of fibroblasts.Semantic proximity Read ↗

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