Article
Dimerization of the polymeric immunoglobulin receptor controls its transcytotic trafficking.
Molecular biology of the cell - 1 Apr 1998
Singer K L, Mostov K E
Abstract excerpt
Binding of dimeric immunoglobulin (Ig)A to the polymeric Ig receptor (pIgR) stimulates transcytosis of pIgR across epithelial cells. Through the generation of a series of pIgR chimeric constructs, we have tested the ability of ligand to promote receptor dimerization and the subsequent role of rec...
Topics
- Animals
- Base Sequence
- Biological Transport
- Cell Membrane
- Cytoplasm
- Dimerization
- Dogs
- Glycophorins
- Humans
- Immunoglobulin A
- Iodine Radioisotopes
- Jurkat Cells
- Molecular Sequence Data
- Mutation
- Receptors, Antigen, T-Cell
- Receptors, Fc
- Recombinant Proteins