Article
Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2006
Bakema Jantine E, de Haij Simone, den Hartog-Jager Constance F, Bakker Johanna, Vidarsson Gestur, van Egmond Marjolein, van de Winkel Jan G J, Leusen Jeanette H W
Abstract excerpt
The prototypic receptor for IgA (FcalphaRI, CD89) is expressed on myeloid cells and can trigger phagocytosis, tumor cell lysis, and release of inflammatory mediators. The functions of FcalphaRI and activating receptors for IgG (FcgammaRI and FcgammaRIII) are dependent on the FcR gamma-chain dimer. This study increases our understanding of the molecular basis of the FcalphaRI-FcR gamma-chain transmembrane...
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