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Mutant p53 partners in crime

3 Nov 2017

Abstract excerpt

Mutant p53 proteins impart changes in cellular behavior and function through interactions with proteins that alter gene expression. The milieu of intracellular proteins available to interact with mutant p53 is context specific and changes with disease, cell type, and environmental conditions. Varying conformations of mutant p53 largely dictate protein-protein interactions as different point mutations within...

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PMID: 29099488
DOI: 10.1038/cdd.2017.185

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