Article
An NMR comparison of the changes produced by different guanosine 5'-triphosphate analogs in wild-type and oncogenic mutant p21ras.
Biochemistry - 27 Jul 1993
Miller A F, Halkides C J, Redfield A G
Abstract excerpt
We have used nuclear magnetic resonance spectroscopy to compare the conformational changes produced by replacement of bound GDP by the GTP analogs guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) and guanylyl (beta, gamma-imido)diphosphate (GMPPNP) in wild-type p21ras as well as the oncogenic mu...
Topics
- Binding Sites
- Glycine
- Guanosine 5'-O-(3-Thiotriphosphate)
- Guanosine Diphosphate
- Guanosine Triphosphate
- Guanylyl Imidodiphosphate
- Humans
- Isoleucine
- Magnetic Resonance Spectroscopy
- Mutation
- Protein Conformation
- Proto-Oncogene Proteins p21(ras)