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Article

Proton NMR studies of transforming and nontransforming H-ras p21 mutants.

Biochemistry - 16 Jan 1990

Schlichting I, John J, Frech M, Chardin P, Wittinghofer A, Zimmermann H, Rösch P

Abstract excerpt

One- and two-dimensional nuclear magnetic resonance spectroscopy (1D and 2D NMR) and site-directed mutagenesis were used to study the influence of mutations on the conformation of the H-ras oncogene product p21. No severe structural differences between the different mutants, whether they were transforming or nontransforming, could be detected. Initially, selective incorporation of 3,5-deuterated tyrosyl residues...

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Identifiers

PMID: 2405906
DOI: 10.1021/bi00454a026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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