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Article

Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy.

FEBS letters - 17 Dec 2004

Spoerner Michael, Wittinghofer Alfred, Kalbitzer Hans Robert

Abstract excerpt

Ras regulates a variety of different signal transduction pathways acting as molecular switch. It was shown by liquid and solid-state (31)P NMR spectroscopy that Ras exists in the guanosine-5'-(beta,gamma-imido)triphosphate bound form in at least two conformational states interconverting in millisecond time scale. The relative population between the two conformational states affects drastically the affinity of Ras...

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Identifiers

PMID: 15589837
DOI: 10.1016/j.febslet.2004.11.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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