Article

NMR 1H, 13C, 15N backbone resonance assignments of wild-type human K-Ras and its oncogenic mutants G12D and G12C bound to GTP

2023-09-21

Abstract excerpt

Human K-Ras protein, which is a member of the GTPase Ras family, hydrolyzes GTP to GDP and concomitantly converts from its active to its inactive state. It is an important oncoprotein, because several mutations, particularly those at residue position 12, occur with a high frequency in a wide range of human cancers. The K-Ras protein is therefore an important target for developing therapeutic anti-cancer agents. In...

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Literature Corpus work: 5db2eed6-b2e4-5d9e-b784-2a3283693160
DOI: 10.21203/rs.3.rs-3345859/v1

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